Chitosan/PEGDA based scaffolds as bioinspired materials to control in vitro angiogenesis
نویسندگان
چکیده
In the current work, our purpose was based on assessment of bioactive chitosan (CS)/Poly(ethylene glycol) diacrylate (PEGDA) scaffolds ability to stimulate in vitro angiogenesis process. The bioactivation accomplished by using organic (BMP-2 peptide) and inorganic (hydroxyapatite nanoparticles) cues. particular, properties materials terms biological response promotion human umbilical vein endothelial cells (HUVECs) were studied tests cell growth proliferation. Furthermore, interest examine capability modulate two important steps involved process: migration tube formation cells. Our data underlined that signals CS/PEGDA surface induce a desirable effect angiogenic concerning marker expression (CD-31) tissue (tube formation). Taken together, results emphasized concept may be novel implants for stimulating neovascularization tissue-engineered constructs regenerative medicine field.
منابع مشابه
Bioinspired structural materials.
Natural structural materials are built at ambient temperature from a fairly limited selection of components. They usually comprise hard and soft phases arranged in complex hierarchical architectures, with characteristic dimensions spanning from the nanoscale to the macroscale. The resulting materials are lightweight and often display unique combinations of strength and toughness, but have prove...
متن کاملBioinspired optofluidic FRET lasers via DNA scaffolds.
Optofluidic dye lasers hold great promise for adaptive photonic devices, compact and wavelength-tunable light sources, and micro total analysis systems. To date, however, nearly all those lasers are directly excited by tuning the pump laser into the gain medium absorption band. Here we demonstrate bioinspired optofluidic dye lasers excited by FRET, in which the donor-acceptor distance, ratio, a...
متن کاملBioinspired Implant Materials Befuddle Bacteria
T he use of biomaterials for implants or medical devices stretches back 35,000 years, when sutures were used to close large wounds. The Greeks and Chinese used gold in dental restorations 2,000 years ago. However, since World War II, all manner of materials have found use in implants or other medical devices, including ceramics such as alumina and hydroxyapatitite; various metals such as stainl...
متن کاملBioinspired Materials for Water Purification
Water scarcity issues associated with inadequate access to clean water and sanitation is a ubiquitous problem occurring globally. Addressing future challenges will require a combination of new technological development in water purification and environmental remediation technology with suitable conservation policies. In this scenario, new bioinspired materials will play a pivotal role in the de...
متن کاملNaturally-derived and bioinspired materials
Cell behavior and tissue function are influenced by the composition and architecture of their surroundings. These cues can drive normal processes during, for example, development, wound healing and homeostasis, or promote harmful processes including tumor growth and metastasis, fibrosis, disease and degeneration. Recent advances in materials synthesis, processing and characterization as well as...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Materials Science and Engineering: C
سال: 2021
ISSN: ['1873-0191', '0928-4931']
DOI: https://doi.org/10.1016/j.msec.2020.111420